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SICCA 2009

The Sjögren’s International Collaborative Clinical Alliance (SICCA) has been funded since 2003 by the National Institute of Dental and Craniofacial Research (NIDCR) to:

  • Develop new classification criteria for Sjogren's syndrome (SS)
  • Better characterize the SS phenotype and genotype
  • Establish an SS data and specimen repository to support future research, including genetic studies, by investigators worldwide 


The Alliance built an international registry of uniform clinical data and biospecimens that is now being made available to scientists all over the world, with the intent of improving understanding and treatment of Sjögren’s syndrome. The SICCA Biospecimen / Data Registry is directed and managed by UCSF professors Lindsey Criswell and Caroline Shiboski and is supported by a NIDCR/NEI grant.

The new classification criteria developed by the SICCA group was recently provisionally approved by the American College of Rheumatology.

SICCA is a multidisciplinary effort that includes dentists (oral medicine and oral pathology specialists), ophthalmologists, rheumatologists, a geneticist, an epidemiologist, and statisticians.

 Clinical data and specimens were collected from 9 participating research sites  N enrolled at baseline:
 University of Buenos Aires, German Hospital, Argentina  441
 Peking Union Medical Collage Hospital, China  333
 Copenhagen University Hospital, Denmark  610
 Kanazawa Medical University, Japan  368
 Aravind Eye Hospital, Madurai India  161
 King’s College London, United Kingdom  312
 University of California, San Francisco, CA USA  718
 University of Pennsylvania, Philadelphia, PA USA  266
 Johns Hopkins, Baltimore, MD USA  305
 Total enrolled at baseline:  3514